MOSCOW, 28 Mar. Scientists from the Tyumen Medical University (TMU), as part of an international research team, have discovered a special marker in patients with prostate cancer, which, according to the authors of the study, makes it possible to identify potentially aggressive tumors, monitor the course of the disease, and select effective antitumor therapy. The results of the study were published in the journal «Non-coding RNA Research».
According to TMU scientists, there are still no reliable markers that would help distinguish aggressive types of prostate cancer from its indolent, non-aggressive forms.
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An international scientific team, with the participation of researchers from TMU, analyzed the activity of microRNA-153 (short non-coding RNA molecules with a high potential for biomarkers) in patients with prostate cancer at different stages.
The study was carried out using the polymerase chain reverse transcription reactions. His results showed that miRNA-153 expression is significantly increased in metastatic prostate tumors compared to non-metastatic ones.
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«To assess the predictive ability of miRNA-153 in relation to metastasis, we analyzed the» error curve » — the ratio of objects that have a feature to all objects. It was found that this microRNA can serve as a potential prognostic marker, with a sensitivity of 72% and a specificity of 86%. We also found that high expression of microRNA-153 increases the risk of metastases by about three times,” said Aferin Beylerli, one of the authors of the study, an assistant at the Department of Obstetrics and Gynecology at TMU.
Researchers from Tyumen State Medical University, Institute of Biochemistry and Genetics of the Ufa Federal Research Center of the Russian Academy of Sciences, Bashkir State Medical University, Sechenov University, Petrovsky National Research Center for Surgery and Harbin Medical University.
In the future, the research team plans to continue the search for miRNAs that can predict the development of tumors prostate towards metastasis. The more markers of aggressiveness of prostate cancer are identified, the more reliable test systems for predicting the course of the disease can be created, scientists believe. «data-url=»https://ria.ru/20221207/sgu-1836742611.html» data->
Tyumen State Medical University is a member of the Priority 2030 program.