MOSCOW, May 17th. A new method of vaccination without injections was created by scientists from SSU, the A.A. Smorodintsev and SPbPU as part of an international scientific team. According to the authors of the development, the vaccine is administered through the hair follicles without damaging the skin. The results of the study, supported by grants from the Russian Science Foundation (RSF), were published in the Journal of Materials Chemistry В.
Vaccination is one of the main strategies for preventing infectious diseases. Traditional vaccines are administered intramuscularly or subcutaneously using needles, which is a painful procedure that violates the integrity of the skin, said specialists from the N.G. Chernyshevsky.
< /span>
As SSU experts explained, there is currently a tendency to replace such approaches with non-injection ones. Particular emphasis is placed on the development of transdermal immunization methods, since the skin contains a large number of innate immune cells, the activation of which is a prerequisite for the development of a strong adaptive immune response.
«
“The introduction of the vaccine into the skin can be done, for example, using microneedles. It is less painful and more effective than conventional needles. However, our team set the task of finding a method of vaccination that would completely avoid physical damage to the skin,” said Yulia Svenskaya, one of the authors of the study, senior researcher at the Laboratory of Remotely Controlled Systems for Theranostics of the Scientific Medical Center of Saratov State University.
1 of 2
2 of 2
1 of 2
2 of 2 » data->
Vaccination through hair follicles has been suggested as a solution. This approach ensures the delivery of the drug to immunologically active cells without the need to break the integrity of the skin, which completely avoids the negative consequences of traditional vaccination protocols.
The method of vaccination through hair follicles was tested experimentally on laboratory animals. The study proposed a novel approach to seasonal influenza vaccination. Submicron spherical calcium carbonate particles of about 0.9 micrometer in size were used as the influenza vaccine carrier. Such a particle size, according to Svenskaya, makes it possible to guarantee the filling of the follicles with the vaccine. en/20230323/yazva-1860121661.html» data->
The authors claim that the method they have developed has special prospects for vaccination and immunotherapy of persons with age-related extinction of immunological reactivity, as well as, for example , with secondary immunodeficiencies.
The study involved scientists from Saratov State University, Peter the Great St. Petersburg Polytechnic University, St. Petersburg Academic University, Sirius University, A.A. Smorodintsev and Queen Mary University of London.