VLADIVOSTOK, July 14 Scientists from the Far Eastern Federal University (FEFU) and the Pacific State Medical University (TSMU) of the Ministry of Health of Russia have synthesized a new material from the skeleton of a marine e which helps to deliver targeted anticancer drugs to tumor cells, it can be used in the treatment of metastatic cancer, said a representative of FEFU.
According to him, antitumor drug therapy in the traditional way usually has a detrimental effect not only on tumor cells, but also on normal cells of the body. This leads to a reduction in doses or a change in therapy to a less effective one. But it is possible to use a drug delivery system: the carrier particle interacts with the drug, retains it and delivers it to the affected organ in a targeted manner for a long time. In this case, chemotherapy becomes less toxic to the body.
«FEFU and TSMU scientists propose to use as The new material for the delivery of the drug is a composite synthesized from the sea urchin Mesocentrotus nudus. The multi-tiered cellular structure of the modified echinoderm skeleton after synthetic processing allows not only to absorb the drug well, but also to gradually release it in small portions,» the source said.
He noted that the scientists modified the obtained composite from the sea urchin with sodium silicate, which made it more resistant to rapid dissolution. This ensures controlled excretion of the drug in the body upon contact with affected cells.
«It was decided to conduct biotesting of the composite on in vitro and in vivo models in further studies. Drug-loaded nanoparticles can release therapeutic doses of the drug for a longer period of time than other systems described in the literature, which means they can prevent tumor recurrence after resection (removal)», said Olesya Kapu, a research laboratory assistant at the Laboratory of Nuclear Technologies of the Institute of High Technologies and Advanced Materials of the Far Eastern Federal University