GENERICO.ruScienceTesting of a domestic mRNA vaccine on mice began in Siberia

Testing of a domestic mRNA vaccine on mice began in Siberia

NOVOSIBIRSK, Oct. 5Scientists at the Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences (IBFM SB RAS) have begun experimental tests on mice of a domestic mRNA vaccine against influenza, which in the future could become a universal model for creating new vaccines and drugs, Grigory, head of the institute’s genome editing laboratory, told reporters Stepanov.
The 2023 Nobel Prize in Medicine was awarded to biochemist Katalin Karikó (Hungary) and immunologist Drew Weissman (USA) for their discoveries in the field of modification of nucleic acid bases, which allowed the development of mRNA vaccines. The work of scientists helped in the creation of vaccines against coronavirus by Moderna and BioNTech/Pfizer. There are no such drugs in Russia yet.

“We are now talking about an mRNA vaccine against influenza A (H1N1). We launched a pilot experiment on mice to test “Does our mRNA protect against influenza? The experiment has been launched,” Stepanov said, commenting on Russian developments related to the topic of Nobel laureates.

The scientist noted that the influenza virus was chosen to create an mRNA vaccine solely as a model that is easy to study: it was necessary to select a “target” for which Russia has all the necessary antibodies.
“Of course, in the near future we will receive mRNA drugs for various infectious diseases. But the uniqueness of this technology lies in the fact that we can present mRNA in the form of a puzzle, in which we know the essential elements that ensure its stability and recognition by the cell as its own own, and in the middle there are those “cubes” on which, in fact, it is written what disease this mRNA vaccine was created against. Replacing these “cubes”, we can change the target…, then we can take any targets, insert them into that same designer and conduct similar experiments in literally all directions we want,” he said.
Thus, according to the scientist, it is possible to use mRNA not only to obtain vaccines as preventive drugs, but also drugs for the treatment of cancer and hereditary diseases, where mRNA drugs can compensate for the malfunction of a gene.
The project to create an mRNA vaccine for influenza is supported by the Russian Science Foundation and is being carried out in the laboratory of the Institute of Chemical Biology and Medicine of the SB RAS with the participation of the Influenza Research Institute of the Ministry of Health of the Russian Federation (St. Petersburg), the Institute of Fine Chemical Technologies (Moscow), and the Russian Technological University.

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