Strong immunity is the basis for protecting a person from viral infections that become widespread during the epidemiological season. The 15th Annual All-Russian Congress on Infectious Diseases named after Academician V.I. Pokrovsky ended in Moscow, during which leading experts discussed modern approaches to the prevention and treatment of ARI. -content/uploads/2023/04/982b6fe951ff290aaebc4220e4aeec85.jpg» />
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With the advent of positive temperatures in early spring, an increase in the incidence of respiratory infections is noted annually. Over the past week in Russia, an increase in the incidence of ARVI and influenza has been recorded compared to last week. The increase was 72.3 per 10,000 population and was 3.3% above the baseline.
An adequate immune response helps protect the body from infection and serious complications. External factors, such as stress, lack of sleep, malnutrition, and infectious diseases, significantly affect immunity. “Weakened” immunity is more susceptible to viruses and often after one disease the patient immediately suffers a new one caused by a viral or bacterial infection.
As part of the symposium “Evidence-based medicine in immunocorrection. Modern approaches to the prevention and treatment of ARI «experts noted that immunocorrectors of complex action can help to transfer the disease in a mild form and strengthen the body's immunity. One of these drugs is azoximer bromide (Polyoxidonium®), which affects all parts of the immune system. It is used for the treatment and prevention of acute and exacerbation of chronic infectious diseases.
Kalyuzhin Oleg Vitalievich, Doctor of Medical Sciences, Professorsummarized the mechanism of action of the drug. «Polyoxidonium®» is an immunocorrector. The drug activates local immunity, increasing the concentration of secretory immunoglobulin sIgA and the production of lysozyme. It affects the adaptive and innate mechanisms of immune defense. It promotes the interaction of T-cells and B-cells, as a result, antibodies are produced that neutralize pathogens, and other antibody-dependent mechanisms of anti-infective defense are launched. In addition, the drug promotes the activation of phagocytosis (the absorption of foreign agents by immune cells) and the prevention of the formation of excessive formation of neutrophil traps (NETos), which, at high concentrations, aggravate the severity of infectious diseases.
During the symposium, physicians made a special emphasis on evidence base of azoximer bromide. According to Gorelov Alexander Vasilyevich, Academician of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor, as a result of a meta-analysis of five clinical studies, it was found that the inclusion of «Polyoxidonium» in the complex treatment of acute and chronic respiratory infections, including influenza and SARS, allows you to better control the symptoms of intoxication, reduce the severity of the infectious and inflammatory process and provide positive influence on immune mechanisms. In addition, azoximer bromide has a favorable safety profile.
The ability of azoximer bromide to strengthen immunity and provide protection during times of increased risk of disease was demonstrated in a scientific study conducted with the participation of medical workers in the «red zones» who took «Polyoxidonium ®”, and other healthcare workers who did not receive immunomodulatory therapy.
“Prophylactic use of the drug significantly reduced the incidence of new COVID-19 infection among healthcare workers. The proportion of patients who took azoximer bromide and eventually survived SARS-CoV-2 was only 2.44% of the total number of participants. While in the comparison group the same indicator is — more than 16%», — shared data Zhdanov Konstantin Valerievich, Corresponding Member of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor.
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